House Majority Whip Kevin McCarthy (R-Calif.), who helped his party capture the lower chamber, predicted Republicans will win control of the Senate.

"Republicans will gain in the Senate... I think they can probably get up to 52," McCarthy said at a breakfast sponsored by the Christian Science Monitor.

Noting that many of the senators up for reelection this year were swept into office during a wave election year in 2006, McCarthy said this will be the first time they've had to run on their record.

"I have this philosophical belief that minorities do not capture majorities, majorities lose majorities... Think about it - who's up for election this year in the Senate? People that came in in [the] '06 and '08 election and they never had to go before the voters with what they voted on," McCarthy said.